IN THE SPOTLIGHT Old Habits Die Hard: Addiction of BRAF-Mutant Cancer Cells to MAP Kinase Signaling
نویسندگان
چکیده
1 Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee. 2 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee. Current address for W. Pao: Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Basel, Switzerland. Corresponding Author: William Pao, 2220 Pierce Avenue 777 PRB, Nashville, TN 37232. Phone: 615-343-9454; Fax: 615-343-7602; E-mail: william. [email protected] doi: 10.1158/2159-8290.CD-15-0221 ©2015 American Association for Cancer Research. Summary: Dual and triple combination therapies with RAF inhibitors plus other targeted agents have demonstrated promising clinical utility in BRAF V600 -mutant solid tumors. However, despite vertical inhibition at multiple nodes on the MAPK signaling pathway, resistant tumors emerge. Ahronian and colleagues show that in BRAF-mutant colorectal cancer, resistance involves reactivation of RAS/RAF/MEK/ERK signaling and may be overcome by newly emerging ERK inhibitors. Cancer Discov; 5(4); 348–50. ©2015 AACR.
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Old Habits Die Hard: Addiction of BRAF-Mutant Cancer Cells to MAP Kinase Signaling.
Dual and triple combination therapies with RAF inhibitors plus other targeted agents have demonstrated promising clinical utility in BRAFV600-mutant solid tumors. However, despite vertical inhibition at multiple nodes on the MAPK signaling pathway, resistant tumors emerge. Ahronian and colleagues show that in BRAF-mutant colorectal cancer, resistance involves reactivation of RAS/RAF/MEK/ERK sig...
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